A 64-year-old man experienced severe visual distortions, resembling a Picasso painting, and various distressing symptoms for six months. After multiple consultations, a diagnosis of CASPR2 antibody-related autoimmune encephalitis was made. Treatment with intravenous immunoglobulin, steroids, and Rituximab significantly improved his condition, highlighting the importance of precise diagnosis and advanced diagnostic tools. A 64-year-old man experienced severe visual distortions, resembling a Picasso painting, and various distressing symptoms for six months. After multiple consultations, a diagnosis of CASPR2 antibody-related autoimmune encephalitis was made. Treatment with intravenous immunoglobulin, steroids, and Rituximab significantly improved his condition, highlighting the importance of precise diagnosis and advanced diagnostic tools. Health and Fitness, Health Tips, Exercises & Workout Tips, Diet & Wellness | Times of India Lifestyle