Dual mechanisms found to guard mitochondria against fusion-related damage

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding mitochondrial integrity through the combined actions of Parkin–PINK1 and OMA1. The study reveals that these stress-responsive systems control mitochondrial fusion under normal physiological conditions. Loss of both proteins leads to severe mitochondrial abnormalities, impaired development, and early mortality in mice. Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding mitochondrial integrity through the combined actions of Parkin–PINK1 and OMA1. The study reveals that these stress-responsive systems control mitochondrial fusion under normal physiological conditions. Loss of both proteins leads to severe mitochondrial abnormalities, impaired development, and early mortality in mice. Cell & Microbiology Molecular & Computational biology Phys.org – latest science and technology news stories