Our bodies and organs are shielded from the external environment by tissue barriers like the skin. These barriers must be tightly sealed to prevent unwanted substances from entering. This sealing is achieved through structures called tight junctions. However, how these tight junctions form has long been a mystery. Our bodies and organs are shielded from the external environment by tissue barriers like the skin. These barriers must be tightly sealed to prevent unwanted substances from entering. This sealing is achieved through structures called tight junctions. However, how these tight junctions form has long been a mystery. Cell & Microbiology Molecular & Computational biology Phys.org – latest science and technology news stories