Exogenous RNA surveillance by proton-sensing TRIM25 | Science

Exogenous RNA surveillance by proton-sensing TRIM25 | Science

Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens with in vitro–transcribed mRNAs in lipid … Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR…

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Integrating multiple evidence streams to understand insect biodiversity change | Science

Integrating multiple evidence streams to understand insect biodiversity change | Science

Insects dominate animal species diversity yet face many threats from anthropogenic drivers of change. Many features of insect ecology make them a challenging group, and the fragmented state of knowledge compromises our ability to make general statements … Insects dominate animal species diversity yet face many threats from anthropogenic drivers of change. Many features of insect…

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Homogeneous-heterogeneous bifunctionality in Pd-catalyzed vinyl acetate synthesis | Science

Homogeneous-heterogeneous bifunctionality in Pd-catalyzed vinyl acetate synthesis | Science

Presently, mechanistic paradigms in catalysis generally posit that the active species remains either homogeneous or heterogeneous throughout the reaction. In this work, we show that a prominent industrial process, palladium (Pd)–catalyzed vinyl acetate … Presently, mechanistic paradigms in catalysis generally posit that the active species remains either homogeneous or heterogeneous throughout the reaction. In this work,…

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Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop | Science

Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop | Science

Human high-order thalamic nuclei activity is known to closely correlate with conscious states. However, it is not clear how those thalamic nuclei and thalamocortical interactions directly contribute to the transient process of human conscious perception. … Human high-order thalamic nuclei activity is known to closely correlate with conscious states. However, it is not clear how those…

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A geological timescale for bacterial evolution and oxygen adaptation | Science

A geological timescale for bacterial evolution and oxygen adaptation | Science

Microbial life has dominated Earth’s history but left a sparse fossil record, greatly hindering our understanding of evolution in deep time. However, bacterial metabolism has left signatures in the geochemical record, most conspicuously the Great … Microbial life has dominated Earth’s history but left a sparse fossil record, greatly hindering our understanding of evolution in deep…

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Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale | Science

Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale | Science

Light-sheet fluorescence microscopy has revolutionized biology by visualizing dynamic cellular processes in three dimensions. However, light scattering in thick tissue and photobleaching of fluorescent reporters limit this method to studying thin or … Light-sheet fluorescence microscopy has revolutionized biology by visualizing dynamic cellular processes in three dimensions. However, light scattering in thick tissue and photobleaching of…

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