Stem-cell states converge in multistage cutaneous squamous cell carcinoma development | Science

Stem cells play a critical role in cancer development by contributing to cell heterogeneity, lineage plasticity, and drug resistance. We created gene expression networks from hundreds of mouse tissue samples (both normal and tumor) and integrated these … Stem cells play a critical role in cancer development by contributing to cell heterogeneity, lineage plasticity, and drug…

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Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer’s disease | Science

Abnormal calcium signaling is a central pathological component of Alzheimer’s disease (AD). Here, we describe the identification of a class of compounds called ReS19-T, which are able to restore calcium homeostasis in cell-based models of tau pathology. … Abnormal calcium signaling is a central pathological component of Alzheimer’s disease (AD). Here, we describe the identification of…

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Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity | Science

Tumors with the same diagnosis can have different molecular profiles and response to treatment. It remains unclear when and why these differences arise. Somatic genomic aberrations occur within the context of a highly variable germline genome. … Tumors with the same diagnosis can have different molecular profiles and response to treatment. It remains unclear when and…

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The Textbooks Were Wrong About How Your Tongue Works

The perception of taste is remarkably complex, not only on the tongue but in organs throughout the body. The perception of taste is remarkably complex, not only on the tongue but in organs throughout the body. Tongue, Taste, Psychology and Psychologists, Brain, Diet and Nutrition, Digestive Tract, your-feed-science NYT > Science

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