New ligand-guided technique enhances drug development

New ligand-guided technique enhances drug development

Achieving a level of precision to create complex medicines and materials with extreme accuracy is a longstanding goal of scientists and pharmaceutical companies. If achieved, that precision could lead to the development of more effective drug treatments. Achieving a level of precision to create complex medicines and materials with extreme accuracy is a longstanding goal of…

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Landslide triggers megatsunami in narrow fjord

Landslide triggers megatsunami in narrow fjord

It was a monster wave that hit a fjord on Greenland’s east coast on 16 September 2023. In certain places, the traces of the flooding reached 200 meters high. Researchers led by Angela Carrillo Ponce from the German Research Centre for Geosciences (GFZ) have now evaluated the seismic signals from earthquake measuring stations worldwide and…

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A ‘thank you’ goes a long way in family relationships

A ‘thank you’ goes a long way in family relationships

You’ve probably heard that cultivating gratitude can boost your happiness. But in marriage and families, it’s not just about being more grateful for your loved ones—it’s also important to feel appreciated by them. Researchers at the University of Illinois Urbana-Champaign have previously explored the positive impact of perceived gratitude from romantic partners on couples’ quality…

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Regulation of the hematopoietic stem cell pool by C-Kit–associated trogocytosis | Science

Regulation of the hematopoietic stem cell pool by C-Kit–associated trogocytosis | Science

Hematopoietic stem cells (HSCs) are routinely mobilized from the bone marrow (BM) to the blood circulation for clinical transplantation. However, the precise mechanisms by which individual stem cells exit the marrow are not understood. This study … Hematopoietic stem cells (HSCs) are routinely mobilized from the bone marrow (BM) to the blood circulation for clinical transplantation….

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Brain region–specific action of ketamine as a rapid antidepressant | Science

Brain region–specific action of ketamine as a rapid antidepressant | Science

Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor (NMDAR), it was not clear whether there is a selective, primary site for … Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of…

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PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation | Science

PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation | Science

Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular processes, many biomolecular condensates exist in a solid-like state, and their function and regulation are less understood. We show that the tumor suppressor … Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular processes, many biomolecular condensates exist in a solid-like state, and their function…

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Ultrafast studies of elusive chemical reactions in the gas phase | Science

Ultrafast studies of elusive chemical reactions in the gas phase | Science

The chemical composition of the interstellar medium and planetary atmospheres is constantly in flux as atoms and molecules collide and interact with high-energy particles such as electrons, protons, and photons. These transformative processes ultimately … The chemical composition of the interstellar medium and planetary atmospheres is constantly in flux as atoms and molecules collide and interact…

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Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates | Science

Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates | Science

Antiviral therapies with reduced frequencies of administration and high barriers to resistance remain a major goal. For HIV, theories have proposed that viral-deletion variants, which conditionally replicate with a basic reproductive ratio [R0] > 1 (… Antiviral therapies with reduced frequencies of administration and high barriers to resistance remain a major goal. For HIV, theories have…

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