Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory viral … Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution…

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Historic manioc genomes illuminate maintenance of diversity under long-lived clonal cultivation | Science

Historic manioc genomes illuminate maintenance of diversity under long-lived clonal cultivation | Science

Manioc—also called cassava and yuca—is among the world’s most important crops, originating in South America in the early Holocene. Domestication for its starchy roots involved a near-total shift from sexual to clonal propagation, and almost all manioc … Manioc—also called cassava and yuca—is among the world’s most important crops, originating in South America in the early…

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A subcellular map of translational machinery composition and regulation at the single-molecule level | Science

A subcellular map of translational machinery composition and regulation at the single-molecule level | Science

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion microscopy (RiboExM) to visualize individual ribosomes and … Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize…

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Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development | Science

Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development | Science

Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disruption results in lifelong metabolic consequences … Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a…

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