Artificial sweetener sucralose affects brain regions controlling hunger and may increase appetite, especially in people with obesity, according to a new study by USC researchers. Despite being calorie-free, sucralose can increase brain activity related to hunger, altering cravings and eating behavior. Artificial sweetener sucralose affects brain regions controlling hunger and may increase appetite, especially in people with obesity, according to a new study by USC researchers. Despite being calorie-free, sucralose can increase brain activity related to hunger, altering cravings and eating behavior. Health and Fitness, Health Tips, Exercises & Workout Tips, Diet & Wellness | Times of India Lifestyle