Actor Christina Applegate has opened up on a podcast about feeling down as a result of what she has to deal with day-to-day as someone living with Multiple Sclerosis. Actor Christina Applegate has opened up on a podcast about feeling down as a result of what she has to deal with day-to-day as someone living with Multiple Sclerosis. Arts, Culture and Entertainment, Popular Culture, Health, Multiple Sclerosis, Streaming Services, Mental Health, Depression Latest business news