Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress | Science

Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress | Science

Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors … Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors …  Science

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