Simplified redesign of proteins can improve ligand binding

In biology, the binding of cellular proteins to molecules called ligands produces myriad functions essential for life, including cell signaling and enzymatic action. In biotechnology and medicine, the ability of researchers to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient biocatalysis, targeted drug delivery systems and sustainable bioremediation solutions. In biology, the binding of cellular proteins to molecules called ligands produces myriad functions essential for life, including cell signaling and enzymatic action. In biotechnology and medicine, the ability of researchers to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient biocatalysis, targeted drug delivery systems and sustainable bioremediation solutions. Biotechnology Molecular & Computational biology Phys.org – latest science and technology news stories